{"id":649,"date":"2021-02-15T10:58:37","date_gmt":"2021-02-15T10:58:37","guid":{"rendered":"http:\/\/www.cscr.in\/nahd\/?page_id=649"},"modified":"2021-05-18T09:32:26","modified_gmt":"2021-05-18T09:32:26","slug":"haplobanking","status":"publish","type":"page","link":"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/","title":{"rendered":"Applications of Induced Pluripotent Stem Cell (iPSC) Technology: Haplobanking"},"content":{"rendered":"<div id=\"pl-649\"  class=\"panel-layout\" ><div id=\"pg-649-0\"  class=\"panel-grid panel-has-style\" ><div class=\"slide-icon-ss panel-row-style panel-row-style-for-649-0\" ><div id=\"pgc-649-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-649-0-0-0\" class=\"widget_text so-panel widget widget_custom_html panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget custom-html-widget\"><div class=\"sp-new-noscroll\">\n\n<!--<div class=\"sp-title-cscr title-mbottom text-center\">\n<!--<h3 class=\"\"><u>Applications of induced pluripotent stem cell technology \u2013 Haplobanking\n<\/u><u>CREATING A BANK OF CELLS HOMOZYGOUS FOR HLA HAPLOTYPES<\/u><\/h3>-->\n\t<!--<h3 class=\"\"><u>Bank of Cells Homozygous for HLA Haplotypes<\/u><\/h3>\n<\/div>-->\n\t\t\n\t<p class=\"text-justify\"> The conversion of somatic cells into induced pluripotent stem cells (iPSCs) and their cell-type specific differentiation have revolutionized the field of regenerative medicine and have raised the prospects of personalized medicine to cure various diseases. Pre-selecting the specific donors for the generation of induced pluripotent stem cell (iPSC) lines enables to develop iPSC banks which can theoretically provide matching cells for recipients worldwide. The haplobanking project involves identifying HLA homozygous donors from the Indian population and generating iPSC lines from their cultured cells through good manufacturing practice (GMP). For the haplobanking program, the Centre for Stem Cell Research has been part of the international consortium through the Department of Biotechnology, Government of India aiming to establish harmonized approaches to generate iPSCs for regenerative medicine applications. The Centre for Stem Cell Research \/ Christian Medical College collaborates with the Blood Stem cell registry DATRI, a non-governmental organization located in\nChennai for the collection of blood samples from suitable donors across India, which are HLA typed and screened for infectious\ndiseases at the Christian Medical College, Vellore. A robust method has been established at Centre for Stem Cell Research to generate iPSC lines from cultured erythroid cells derived from peripheral blood mononuclear cells (PBMNCs).<\/p>\t\n\n\t\t\t\t\n<div class=\"sp-sec1-1 \">\n<p style=\"margin:0\">\n\t<img style=\"\" src=\"http:\/\/www.cscr.res.in\/nahd\/jb-content\/uploads\/2021\/03\/hapsl-1.jpg\" alt=\"andibody-screening\" width=\"\" height=\"\" class=\"aligncenter andibody-screening1 sp-l1\">\t\n\t\n\t<img style=\"\" src=\"http:\/\/www.cscr.res.in\/nahd\/jb-content\/uploads\/2021\/05\/ha-sp1.jpg\" alt=\"andibody-screening\" width=\"\" height=\"\" class=\"aligncenter andibody-screening2 sp-l2\">\t\n\t<\/p>\t\t\t\t\n\t<\/div>\n<br><br>\n\t<p style=\"margin-bottom: 0px;text-align:center;\">        \n\t\t<span class=\"color-bold-1\">Figure:<\/span> HAPLOBANKING-Schematic overview for the generation of induced pluripotent stem cell (iPSCs) from HLA homozygous individuals from the Indian population.\n<\/p>\n\t\t<!--\t<div class=\"img-cap-span\">\n\t\t\t\tHAPLOBANKING-Schematic overview for the generation of induced pluripotent stem cell (iPSCs) from HLA homozygous individuals from the Indian population.\t\n\t\t\t<\/div>-->\n<br>\n\n\n<\/div>\n\n\n\n\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-649-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-649-1-0\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><div id=\"pgc-649-1-1\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><div id=\"pgc-649-1-2\"  class=\"panel-grid-cell\" ><div id=\"panel-649-1-2-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"so-widget-sow-button so-widget-sow-button-wire-d47fdd289bb7\"><div class=\"ow-button-base ow-button-align-center\">\n\t<a href=\"http:\/\/www.cscr.res.in\/nahd\/\" class=\"ow-icon-placement-left ow-button-hover\" \t\t>\n\t\t<span>\n\t\t\t<span class=\"sow-icon-fontawesome sow-far\" data-sow-icon=\"&#xf0a5;\"\n\t\t ><\/span>\n\t\t\tBack to Home\t\t<\/span>\n\t<\/a>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The conversion of somatic cells into induced pluripotent stem cells (iPSCs) and their cell-type specific differentiation have revolutionized the field of regenerative medicine and have raised the prospects of personalized medicine to cure various diseases. Pre-selecting the specific donors for the generation of induced pluripotent stem cell (iPSC) lines enables to develop iPSC banks which [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"pages\/right-sidebar-7.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v16.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Applications of Induced Pluripotent Stem Cell (iPSC) Technology: Haplobanking - CSCR NAHD<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Applications of Induced Pluripotent Stem Cell (iPSC) Technology: Haplobanking - CSCR NAHD\" \/>\r\n<meta property=\"og:description\" content=\"The conversion of somatic cells into induced pluripotent stem cells (iPSCs) and their cell-type specific differentiation have revolutionized the field of regenerative medicine and have raised the prospects of personalized medicine to cure various diseases. Pre-selecting the specific donors for the generation of induced pluripotent stem cell (iPSC) lines enables to develop iPSC banks which [&hellip;]\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/\" \/>\r\n<meta property=\"og:site_name\" content=\"CSCR NAHD\" \/>\r\n<meta property=\"article:modified_time\" content=\"2021-05-18T09:32:26+00:00\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/#website\",\"url\":\"https:\/\/www.cscr.res.in\/nahd\/\",\"name\":\"CSCR NAHD\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/www.cscr.res.in\/nahd\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/#webpage\",\"url\":\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/\",\"name\":\"Applications of Induced Pluripotent Stem Cell (iPSC) Technology: Haplobanking - CSCR NAHD\",\"isPartOf\":{\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/#website\"},\"datePublished\":\"2021-02-15T10:58:37+00:00\",\"dateModified\":\"2021-05-18T09:32:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/\",\"url\":\"https:\/\/www.cscr.res.in\/nahd\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@id\":\"https:\/\/www.cscr.res.in\/nahd\/haplobanking\/#webpage\"}}]}]}<\/script>\r\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/pages\/649"}],"collection":[{"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/comments?post=649"}],"version-history":[{"count":106,"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/pages\/649\/revisions"}],"predecessor-version":[{"id":3028,"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/pages\/649\/revisions\/3028"}],"wp:attachment":[{"href":"https:\/\/www.cscr.res.in\/nahd\/wp-json\/wp\/v2\/media?parent=649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}