{"id":1086,"date":"2021-03-02T09:02:45","date_gmt":"2021-03-02T09:02:45","guid":{"rendered":"http:\/\/www.cscr.in\/nahd\/?p=1086"},"modified":"2021-05-10T10:43:49","modified_gmt":"2021-05-10T10:43:49","slug":"gene-editing-approach-for-haemoglobinopathies","status":"publish","type":"post","link":"https:\/\/www.cscr.res.in\/nahd\/gene-editing-approach-for-haemoglobinopathies\/","title":{"rendered":"Gene Editing Approach for Haemoglobinopathies"},"content":{"rendered":"<div id=\"pl-1086\"  class=\"panel-layout\" ><div id=\"pg-1086-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-1086-0\" ><div id=\"pgc-1086-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1086-0-0-0\" class=\"widget_text so-panel widget widget_custom_html panel-first-child\" data-index=\"0\" ><div class=\"textwidget custom-html-widget\"><div class=\"sp-title-cscr-post title-mbottom text-left\">\n<h3>Gene Editing Approach for Haemoglobinopathies<\/h3>\n<\/div>\n\t<ul class=\"list-post-sp\">\n\t<li>Novel targets have been identified in the BCL11A enhancer for gene editing to increase HbF<\/li>\n\t<li>A method has been established to generate an HPFH-like deletion in the beta globin cluster in haematopoietic progenitors and has been tested in NBSGW mice to test its potential to increase HbF in human erythroid cells.<\/li>\t\t\t\n<\/ul>\n<\/div><\/div><div id=\"panel-1086-0-0-1\" class=\"widget_text so-panel widget widget_custom_html\" data-index=\"1\" ><div class=\"textwidget custom-html-widget\"><div class=\"sp-co-sub\">\n<p>\n<span class=\"color-red\">Principal Investigator:<\/span><br>\n\t<a class=\"ref-color-anchor-black\" href=\"http:\/\/www.cscr.res.in\/dr-saravanabhavan-thangavel\/\" target=\"_blank\" rel=\"noopener\"><span class=\"color-bold-1\">Dr. Saravanabhavan Thangavel,<\/span> <span class=\"inves-dept\">CSCR, Vellore<\/span><\/a><br>\n\t<a class=\"ref-color-anchor-black\" href=\"http:\/\/www.cscr.res.in\/dr-mohankumar-k-murugesan\/\" target=\"_blank\" rel=\"noopener\"><span class=\"color-bold-1\">Dr. Mohankumar Murugesan,<\/span> <span class=\"inves-dept\">CSCR, Vellore<\/span><\/a>\n<\/p>  \t\n<\/div>\n<\/div><\/div><div id=\"panel-1086-0-0-2\" class=\"so-panel widget widget_media_image panel-last-child\" data-index=\"2\" ><img width=\"410\" height=\"230\" src=\"https:\/\/www.cscr.res.in\/nahd\/jb-content\/uploads\/2021\/03\/gene-post.jpg\" class=\"image wp-image-1803  attachment-full size-full\" alt=\"gene-post\" loading=\"lazy\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/www.cscr.res.in\/nahd\/jb-content\/uploads\/2021\/03\/gene-post.jpg 410w, https:\/\/www.cscr.res.in\/nahd\/jb-content\/uploads\/2021\/03\/gene-post-300x168.jpg 300w\" sizes=\"(max-width: 410px) 100vw, 410px\" \/><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Gene Editing Approach for Haemoglobinopathies Novel targets have been identified in the BCL11A enhancer for gene editing to increase HbF A method has been established to generate an HPFH-like deletion in the beta globin cluster in haematopoietic progenitors and has been tested in NBSGW mice to test its potential to increase HbF in human erythroid [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1803,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v16.3 - 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