Scientific Program

                     PROGRAMME SCHEDULE (Tentative)

Time shown in IST (Indian Standard Time)                                                    

                                     DAY-1: Thursday, 1st  SEPTEMBER, 2022

1:00 to 1:05 PM

1:05 to 1:20 PM

1:20 to 1:30 PM

Prayer by Chaplain

Welcome and introductory remarks: Director, CMC / Principal, CMC / Director, inStem/ Head, CSCR

Remarks by Secretary, Department of Biotechnology, Ministry of Science and Technology, Govt. of India

Session-1:  APPLICATIONS OF iPSC TECHNOLOGY

Indian Time Title Speaker Name

1.30 to 2:00 PM

Consistency and reliability of quality testing for induced Pluripotent Stem Cells

 

Stephen Sullivan
Global Alliance for iPSC Therapies, UK

2:00 to 2:30 PM Assuring reproducibility: Sharing data on hPSC – lines and clinical trials

Andreas Kurtz                                                                                                  Charité-Universitäts medizin Berlin, Berlin, Germany

2:30 to 3:00 PM Creation of a Haplobank- Initiative in India

Dolly Daniel                                                                                                          Christian Medical college and Centre for Stem Cell Research, Vellore, India

3:00 to 3:15 PM                                                                                                    Break
3:15 to 3:45 PM

                                                         Poster presentation/ Industry Symposium

Session-2:  IMMUNE CELL THERAPY 

Indian Time Title Speaker Name
3:45 to 4:15 PM CAR-T

Hasmukh Jain                                                                                            Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, India

4:15 to 4:45 PM

 

Translation of CAR-T cells for cancer immunotherapy: from bench-to-bedside

Anat Globerson                                                                                                        Dana-Dwek Children’s Hospital, TelAviv, Israel

4:45 to 5:15 PM

CAR-T cell therapy for haematological malignancies or solid tumours

Avery D. Posey                                                                                                           University of Pennsylvania, Philadelphia, USA

5:15 to 5:30PM                                                                                                  Break

Session-3: GENE THERAPY

Indian Time Title Speaker Name
5:30 to 6:00 PM

Nongenotoxic conditioning for transplant of genetically engineered HSCs: Is this the future for HSC-based gene therapy

Trent Spencer                                                                                                          Emory University School of Medicine, Atlanta, GA, USA

6:00 to 6:30 PM Gene Therapy for Platelet Derived Factor VIII Production in Hemophilia A

David Wilcox                                                                                                      Medical College of Wisconsin, US

6:30 to 7:00 PM lentiviral vector-based gene therapy for Haemophilia B

Alok Srivastava                                                                                                      Christian Medical college and Centre for Stem Cell Research, Vellore, India

KEY NOTE ADDRESS
7:00 to 8:00 PM TBC

Luigi Naldini                                                                                                                San Raffaele Telethon Institute for Gene Therapy, Milano, Italy

End of Day-1

                                            DAY-2: Friday, 2nd SEPTEMBER, 2022

Session-4: TECHNOLOGY ADVANCES
Indian Time Title Speaker Name
2:00 to 2:30 PM Assessing and mitigating off-target effects in therapeutic genome editing

Toni Cathomen                                                                             Institute of Transfusion Medicine and Gene Therapy, Germany

2:30 to 3:00 PM IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

Sebastien Lacroix-Desmazes                                                            Centre de Recherche des Cordeliers, France

3:00 to 3:30 PM

Base editors mediated gamma globin promoter screening

Mohankumar Murugesan                                                                      Centre for Stem Cell Research, Vellore, India

3:30 to 4:00 PM

Development of optimized (“Opt”) and generation Y (“GenY”) AAVrh74 vectors for gene therapy of muscular dystrophies

Arun Srivastava                                                                                  University of Florida, Florida, USA

4:00 to 4:15 PM  Break

Industry Symposium

Indian Time Title Speaker Name
4:15 to 4:45 PM   TBD
4:45 to 5:15 PM  

TBD

5:15 to 6:00 PM                                                                Poster presentation

Session-6: MANUFACTURING AND REGULATORY ASPECTS IN CELL AND GENE THERAPY 

Indian Time Title Speaker Name
6:00 to 6:30 PM

 

 

Manufacturing of Lentiviral vector for Haemophilia A

 

Lentiviral mediated genetic modification of HSC from Haemophilia A patients

 

 

William Swaney                                                                           Expression Manufacturing LLC, Georgia, USA

Gurbind Singh                                                                                          Centre for Stem Cell Research, Vellore, India

6:30 to 7:00 PM

Advanced HSC clinical trials in the Necker hospital GMP facility

Elisa Magrin and Jihene Benlagha                                        Necker-Enfants Malades Hospital, Paris

7:00 to 7:30 PM Manufacturing of cellular product for clinical application 

Adrian Gee                                                                                                Baylor College of Medicine Houston, TX, US

KEY NOTE ADDRESS

7:30 to 8:30 PM Evolution of lentiviral vector mediated gene modified autologous HSCs for the treatment of hemoglobin disorders

Mark Walters                                                                                          UCSF Benioff Children’s Hospitals, California, USA

End of Day-2

                                                     DAY-3: Saturday, 3rd SEPTEMBER, 2022

                                                                        Session-7: CELL AND GENE THERAPY- INDUSTRY UPDATES
Indian Time Title Speaker Name
2:00 to 2:30 PM Future of Vaccinology-mRNA

Ajay Singh                                                                                   Gennova Biopharma Ltd., Pune, India

2:30 to 3:00 PM

CAR-T cell Therapy-Bench to Bedside-the Immuneel approach

Anil Kamat                                                                               Immuneel Therapeutics Private Limited, Bangalore

 

3:00 to 3:30 PM Allogeneic, Off the Shelf, Pooled, Bone marrow derived Mesenchymal Stromal Cells (Stempeucel®) – a Potential break through therapy for Grade II & III Osteoarthritis knee

Pawan Kumar Gupta                                                    Stempeutics Research Pvt. Ltd., Bangalore

3:30 to 3:45 PM

                                                                                                   Break

Session-8: GENE EDITING
India Time Title Speaker Name
3:45 to 4:15 PM

A Mutation-Agnostic Hematopoietic Stem Cell Gene editing approach

Justin Selvaraj                                                                      University of Tübingen, Germany

4:15 to 4:45 PM

Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases

Annarita Miccio                                                                      Institute of genetic diseases Imagine, Paris Cite’ University, Paris, France

4:45 to 5:15 PM The CD34+CD90+HSCs as a target cell for CCR5 gene editing

Saravanabhavan Thangavel                                                  Centre for Stem Cell Research, Vellore, India

5:15 to 6:00 PM

                                                    Poster presentation/ Industry Symposium

Session-9: NON-VIRAL NUCLEIC ACID TRANSFER

India Time Title Speaker Name
6:00 to 6:30 PM Smart lipid nanoparticle enabled mRNA vaccine for SARS-CoV2

Srujan Marepally                                                                    Centre for Stem Cell Research, Vellore, India

6:30 to 7:00 PM

Therapeutic applications of Cell penetrating siRNAs

Oommen P. Oommen                                                        Tampere University and BioMediTech Institute, Finland

7:00 to 7:30 PM

Lipid nanoparticles T cell specific nucleic acid delivery in vivo

Gaurav Saha                                                                                        Oregon State University, Oregon, US

End of Day-3