10TH ANNUAL CELL AND GENE THERAPY SYMPOSIUM

Progress towards Clinical Reality
10th & 11th October 2025
Christian Medical College Campus, Bagayam, Vellore
Organized by: Centre for Stem Cell Research (a unit of BRIC-inStem, Bengaluru)

DAY 1: Friday, 10th October 2025

6:30 AM Onwards REGISTRATION
8:00 to 8:45 AM BREAKFAST AND TEA at Scudder Auditorium
Hall A
MANUFACTURING AND REGULATORY ASPECTS IN CELL AND GENE THERAPY
Chairs:
Dr. Punam Malik, Cincinnati Children's Hospital Medical Center, USA
Dr. Jyothi Prasanna S, Manipal Institute of Regenerative Medicine, Bengaluru, India
8:45 to 9:10 AM SAGES: Development and Translation of a Novel CRISPR Genome Editing Therapy to Induce Fetal Hemoglobin for Sickle Cell Disease
Jonathan Yen
St. Jude Children's Research Hospital, Memphis, TN
9:10 to 9:35 AM Configuring Chimeric Antigen Receptors for safety and efficacy
Sunil Martin
BRIC-Rajiv Gandhi Centre for Biotechnology, Kerala, India
9:35 to 10:00 AM Robust Manufacturing of NK cells towards development of Allogeneic Therapies
Priyadarshini Chatterjee
Aurigene Oncology Ltd., Bangalore
10:00 to 10:25 AM (IST)
12:30 to 12:55 AM (EDT)
What No T Cell Has Treated Before: Advances in CAR Design and Delivery to Patients
Bruce L. Levine
University of Pennsylvania, Philadelphia, PA
Hall B
POPULATION SCREENING & MANAGEMENT OF GENETIC DISORDERS
Chairs:
Dr. Sumita Danda, Christian Medical College Vellore, India
Dr. VGM Naidu, National Institutes of Pharmaceutical Education and Research, Guwahati, India
8:45 to 9:10 AM Sickle Cell Anaemia: Kal, Aaj, aur Kal (Past, Present and Future)
Giriraj Chandak
Centre for Cellular and Molecular Biology Hyderabad, India
9:10 to 9:35 AM Population based screening of Genetic Disease: A tip for prevention of hemoglobinopathies
Chinmayee Panda
Kalinga Institute of Medical Sciences, Bhubaneswar, India
9:35 to 10:00 AM Genetic screening of pheochromocytoma 'susceptibility genes': CMC experience
Rekha Pai
Christian Medical College Vellore, India
10:00 to 10:25 AM Personal Genomes are Moving the needle for Precision Medicine
Vinod Scaria
Karkinos Healthcare Private Limited, Bengaluru, India
10:25 to 10:45 AM TEA BREAK
Hall A
CELL AND GENE THERAPY
Chairs:
Dr. Aby Abraham, Christian Medical College Vellore, India
Dr. Eunice Sindhuvi, Christian Medical College Vellore, India
10:45 to 11:10 AM Current status, challenges and opportunities with CAR-T cell therapy in India
Vikram Mathews
Christian Medical College Vellore, India
11:10 to 11:35 AM Gene Therapy for Sickle Cell Disease: State of the Field and Beyond
Punam Malik
Cincinnati Children's Hospital Medical Center, USA
11:35 AM to 12:00 PM Cellular model for haematological diseases
Shaji R Velayudhan
Centre for Stem Cell Research, Christian Medical College Vellore, India
12:00 to 12:25 PM Pancreatic Islet Cell Transplantation for the treatment of Diabetes
Balamurugan N Appakalai
University of Louisville/Norton Healthcare, Louisville, USA
Hall B
ORGANOIDS AND DISEASE MODELLING
Chairs:
Dr. Barun Mahata, BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
Dr. Joe Varghese, Christian Medical College Vellore, India
10:45 to 11:10 AM Human 3D organoids as a preclinical platform for intervention testing
Arvind Ramanathan
BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
11:10 to 11:35 AM Harnessing the potential of human liver organoid developed from cells isolated from healthy individuals and patients to develop therapeutics and precision medicines against non-alcoholic fatty liver disease
Ruchi Tandon
Translational Health Science and Technology Institute, Faridabad, India
11:35 AM to 12:00 PM Stem cell derived organoid models to study eye diseases and to validate newer drugs
Indumathi Mariappan
L V Prasad Eye Institute (LVPEI), Hyderabad, India
12:00 to 12:25 PM Guiding Next-Generation Therapies with Stem Cells
Maneesha S. Inamdar
BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
12:25 to 12:55 PM Scientific Talk by Dr. Rajesh S. Gokhale, Secretary, Department of Biotechnology, Ministry of Science and Technology, Govt. of India
at Hall A
1:00 to 1:45 PM Inauguration and address by the Hon'ble Minister
Dr. Jitendra Singh, Minister of State for Science & Technology (I/C), Government of India, New Delhi, India
at Hall A
1:45 to 2:45 PM LUNCH at Scudder Lawn
2:45 to 4:00 PM POSTER SESSION AND QUIZ COMPETITION
Hall A
MESENCHYMAL STEM CELLS (MSCs) AND THEIR SECRETOME
Chairs:
Dr. Indumathi Mariappan, L V Prasad Eye Institute (LVPEI), Hyderabad, India
Dr. Jayakanthan K, Post Graduate Institute of Medical Education & Research, Chandigarh, India
4:00 to 4:25 PM Modeling Vascular Pathophysiology in ACDC Disease Using Gene-Edited Human Aortic Endothelial Cells and Patient-Derived iPSC-based systems
Jyothi Prasanna S
Manipal Institute of Regenerative Medicine, Bengaluru, India
4:25 to 4:50 PM (IST)
11:55 AM to 12:20 PM (BST)
Articular cartilage repair and regeneration – are we there yet?
Ilyas Khan
Swansea University Medical School, Wales, United Kingdom
4:50 to 5:15 PM Potential of Wharton's Jelly Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Managing Metabolic Syndrome in an Animal Model
Yogeswaran Lokanathan
Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
5:15 to 5:40 PM MSCs in the clinic – Current status & future prospects
Pawan K Gupta
Stempeutics Research, Bangalore, India
Hall B
MOLECULAR GENETICS OF INHERITED DISEASES
Chairs:
Dr. Vinod Scaria, Karkinos Healthcare Private Limited, Bengaluru, India
Dr. Alan Mathew Punnoose, SRIHER- Sri Ramachandra Institute of Higher Education and Research, Chennai, India
4:00 to 4:25 PM Deciphering the "omics" for Alkaptonuria
Sumita Danda
Christian Medical College Vellore, India
4:25 to 4:50 PM Population Genomes to Precision Medicine – Impact on Public Health in India
Sridhar Sivasubbu
Karkinos Healthcare Pvt Ltd, Mumbai, India
4:50 to 5:15 PM Genetics of Insulin Secretion: Insights from massive parallel sequencing
Aaron Chapla
Christian Medical College Vellore, India
5:15 to 5:40 PM Mission program in pediatric rare genetic disorders
Ashwin Dalal
Centre for DNA Fingerprinting and Diagnostics Hyderabad, India
5:40 to 6:15 PM TEA BREAK AND INDUSTRY EXHIBITION
KEYNOTE ADDRESS
Chair: Dr. Vikram Mathews, Christian Medical College Vellore, India
6:15 to 7:00 PM (IST)
7:45 to 8:30 AM (CDT)
Gene Therapy for Hemoglobinopathies: Recent Developments and Ongoing Challenges
Mitchell Weiss
St. Jude Children's Research Hospital, Memphis, USA
7:00 PM onwards CULTURAL PROGRAM AND DINNER at Eden Garden

DAY 2: Saturday, 11th October 2025

8:00 AM to 11:00 AM REGISTRATION
8:00 to 9:00 AM BREAKFAST at Scudder Lawn
Hall A
INDUSTRY UPDATES
Chairs:
Dr. Priyadarshini Chatterjee, Aurigene Oncology Ltd., Bangalore, India
Dr. Rajkumar Banerjee, CSIR-Indian Institute of Chemical Technology, Hyderabad, India
9:00 to 9:20 AM From Discovery to Cure: Bridging the gap between Innovation and Application
Prathap Naidu
Thermo Fisher Scientific
9:20 to 9:40 AM Driving CAR T Cell Innovation with Agilent's Integrated Analytical Platforms
Vadiraja Bhat
Agilent Technologies India Pvt Ltd.
9:40 to 10:00 AM Cytokine Profiling in Cell & Gene Therapy: Bridging Mechanistic Insight and Translational Impact
Anisha Polley Sikder
Krishgen Biosystems PVT. Ltd., Mumbai, India
10:00 to 10:10 AM Turning Biology for Therapy: MSc's, T cells and 3D Cell Culture
Priti Warke
HiMedia Laboratories
10:10 to 10:30 AM Allogenic Off-the-shelf Natural Killer (NK) Cell therapy for Cancers
Renjitha Gopurappilly
NKure Therapeutics Pvt Ltd (CCAMP), Miltenyi Biotec
10:30 to 10:40 AM Facilitating manufacturing of GMP grade reagents for Cell and Gene therapy in India
Kodo Lifescience Pvt Ltd
Hall B
CELL THERAPY FOR HEMATOLOGICAL DISORDERS
Chairs:
Dr. Everette J R Nelson, Vellore Institute of Technology, Vellore, India
Dr. Poonkuzhali B., Christian Medical College, Vellore, India
9:00 to 9:25 AM Looking beyond matched sibling donor transplants for hematological malignancies
Biju George
Christian Medical College Vellore, India
9:25 to 9:50 AM Lentiviral gene therapy for haemophilia A- an update of the clinical trial
Aby Abraham
Christian Medical College Vellore, India
9:50 to 10:15 AM Toward Safer Therapies: Development of DNA Break-Free Genome Editing for Various Genetic Disorders
Mohankumar K.M.
Centre For Stem Cell Research, Christian Medical College Vellore, India
10:15 to 10:40 AM Gene-Edited Allogeneic CAR-T Cells for B-Cell Malignancies
Thiyagaraj Mayuranathan
Centre For Stem Cell Research, Christian Medical College Vellore, India
10:40 to 11:25 AM TEA BREAK AND POSTER EXHIBITION
Hall A
IMMUNE MODULATION IN THERAPY
Chairs:
Dr. B. Ashokkumar, Madurai Kamaraj University, Madurai, India
Dr. Vijayalekshmi B, Christian Medical College Vellore, India
11:25 to 11:50 AM Gut–Lung Crosstalk: Harnessing Immunomodulation for Asthma Therapy
Kiran Kumar MN
JSS Academy of Higher Education & Research, Mysuru, India
11:50 AM to 12:15 PM From HIV Biology to lentiviral vectors: Insights into the mechanisms of antiviral actions
Ajit Chande
Indian Institute of Science Education and Research, Bhopal, India
12:15 to 12:40 PM Targeting the Uroseptic Infection with Mesenchymal Stromal Cells and Peptides: Pilot Signals and a Path to Translation
Aruna Rakha Arora
Postgraduate Institute of Medical Education and Research, Chandigarh, India
Hall B
MICROBIAL INFECTIONS CHALLENGES WAY FORWARD
Chairs:
Dr. Siddhardha Busi, Pondicherry University, India
Dr. Supraja Srivastava, Christian Medical College Vellore, India
11:25 to 11:50 AM Newer molecular approach in infectious disease diagnosis
Balaji Veeraraghavan
Christian Medical College Vellore, India
11:50 AM to 12:15 PM Neglected Tropical Diseases: Improving Diagnostics for Helminth Elimination and Control Programs
Sitara Swarna Rao Ajjampur
Christian Medical College Vellore, India
12:15 to 12:40 PM Uncovering the burden of Riboflavin transporter deficiency among Indians: metabolic insights and emerging strategies for gene therapy
B. Ashokkumar
Madurai Kamaraj University, Madurai, India
12:40 to 1:10 PM LUNCH BREAK at Scudder Lawn
Hall A
GENE EDITING
Chairs:
Dr. Jonathan Yen, St. Jude Children's Research Hospital, USA
Dr. R. Vinayagamoorthi, Indira Gandhi Medical College & Research Institute, Government of Puducherry Institution, Pondicherry, India
1:10 to 1:35 PM Development of Precision Genome and Transcriptome Engineering Technologies
Tan Meng How
Nanyang Technological University, Singapore
1:35 to 2:00 PM Use of precision editing, PROTACs to investigate mechanism of neurodevelopmental disorders
Pradeepa Madapura
Queen Mary University of London, London, UK
2:00 to 2:25 PM DYRK1A, a Down Syndrome-linked gene, regulates mTOR signaling
Manish Jaiswal
Tata Institute of Fundamental Research, Hyderabad, India
Hall B
TECHNOLOGY ADVANCES
Chairs:
Dr. Arabinda Chaudhuri, Indian Institute of Science Education and Research (IISER) Kolkata, India
Dr. Ullas Kothur-Seetharam, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
1:10 to 1:35 PM Large-molecule discovery platform supporting fundamental and translational research
Minhaj Sirajuddin
BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
1:35 to 2:00 PM Cadherin-dependent junction formation in driving metabolic reprogramming of cell clusters
Sunil Laxman
BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
2:00 to 2:25 PM tRNA-Derived Small RNAs: Molecular Tuners of Stem Cell State
Dasaradhi Palakodeti
BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
Hall A
YOUNG PROMISES IN RESEARCH
Chairs:
Dr. Kumar Pranav Narayan, Birla Institute of Technology & Science, Pilani Hyderabad Campus, Telangana, India
Dr. Sunil Laxman, BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bangalore, India
2:25 to 2:40 PM Adaptive Quasi-Quiescence Induced Glioblastoma Survival on Emulsion Copolymer Matrix Surface
Subhasish Sahoo
CSIR-Indian Institute of Chemical Technology, Hyderabad, India
2:40 to 2:55 PM Titers Up, Prices Down: Lentiviral Gene Therapy for Globinopathies at a Discount
Karthik C
Centre For Stem Cell Research, Christian Medical College Vellore, India
2:55 to 3:10 PM Targeted base editing enables safe and efficient knockout of ELANE for the treatment of ELANE-associated severe congenital neutropenia
Lokesh Panigrahi
Centre For Stem Cell Research, Christian Medical College Vellore, India
3:10 to 3:25 PM Engineering Non-Viral Gene Delivery Vectors: Balancing Transfection Efficiency and Cytotoxicity for Cell-Specific Targeting
Venkatesh Ravula
Institute for Stem Cell Science and Regenerative Medicine (BRIC-inStem), Bangalore, Karnataka, India
3:25 to 3:40 PM Engineering biomimetic bone marrow niche with gene modified Mesenchymal Stromal Cells for ex vivo culture of human Hematopoietic Stem and Progenitor cells
Sevanthy Suresh
Centre For Stem Cell Research, Christian Medical College Vellore, India
Hall B
METABOLIC DISORDERS AND NOVEL THERAPEUTIC STRATEGIES
Chairs:
Dr. Muthuraman N, Christian Medical College Vellore, India
Dr. Diya Binoy Joseph, BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
2:25 to 2:50 PM Diabetes In the Young in South Asia, the Pathogenesis, Differentials and the Road to Type 5 Diabetes
Nihal Thomas
Christian Medical College and Centre for Stem Cell Research, Vellore, India
2:50 to 3:15 PM Metabolic Orchestration of Cellular Reprogramming: Towards Harnessing Epigenetic and Mitochondrial Networks for Next-Generation Cell and Gene Therapies
Ullas Kothur-Seetharam
Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
3:15 to 3:40 PM Boosting anti-cancer vaccine by "FORTY" fying immunity to achieve tumor free survival
Jayanta Bhattacharyya
Indian Institute of Technology Delhi, New Delhi, India
3:40 to 4:00 PM TEA BREAK AND COMPANY EXHIBITION
Hall A
NEW FRONTIER OF CELL THERAPY
Chairs:
Dr. Shaji R Velayudhan, Centre for Stem Cell Research, Christian Medical College Vellore, India
Dr. Vasanth Thamodaran, Tata Institute for Genetics and Society, Bengaluru, India
4:00 to 4:25 PM (IST)
11:30 to 11:55 AM (BST)
CAR T-cell immunotherapy of NKG2D-expressing solid tumours
John Maher
King's College, London, UK
4:25 to 4:50 PM (IST)
5:55 to 6:20 AM (CDT)
Gene therapy for sickle cell disease – current state and future directions
Akshay Sharma
St. Jude Children's Research Hospital, Memphis, USA
4:50 to 5:15 PM (IST)
4:20 to 4:45 AM (PDT)
A Lentiviral-Based Gene Modified Hematopoietic Stem Cells Approach for HIV-1 Cure Lead to Partial Protection of Uninfected Cells but also Leads to Ongoing Lentiviral RNA Expression, a Risk for Potential Persistent Inflammation
Timothy Henrich
University of California San Francisco, San Francisco, CA
Hall B
ADVANCES IN PRECISION THERAPEUTICS
Chairs:
Dr. Tan Meng How, Nanyang Technological University, Singapore
Dr. Pradeepa Madapura, Queen Mary University of London, London, UK
4:00 to 4:25 PM Glucocorticoid receptor: a potent target for drug sensitization, immuno-modulation in nano-therapeutic strategy for cancer
Rajkumar Banerjee
CSIR-Indian Institute of Chemical Technology, Hyderabad, India
4:25 to 4:50 PM Gene edited hematopoietic stem cells for the gene therapy for beta-hemoglobinopathies
Saravanabhavan Thangavel
Centre For Stem Cell Research, Christian Medical College Vellore, India
4:50 to 5:15 PM AAV9-WWOX gene therapy, a promising treatment for children with WOREE syndrome
Srinivasarao Repudi
BRIC-Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, India
5:15 to 6:00 PM RESULT ANNOUNCEMENT AND CLOSING REMARKS (Hall A)
7:00 PM onwards DINNER at CSCR Roof Top