Dr. Elizabeth Vinod

Academic Qualifications

• M.B.B.S. (January 2006): Annamalai University, Rajah Muthiah Medical College, Chidambaram M.D. PHYSIOLOGY (April 2014): M.G.R University, Christian Medical College, Vellore.

Current Post

• Physician ( Associate Professor)/ Adjunct Scientist Department of Physiology / Centre for Stem Cell Research Christian Medical College, Vellore.

Travel Grants

• Centre for Stem Cell Research to attend and present a poster at the Orthopaedics Research Society Annual Meeting, held at Phoenix, Arizona, USA. February 2020.
• Junior Research Training Fellowship, Christian Medical College, Vellore to Erasmus Medical Center, Rotterdam, Netherlands November 2018
• Indian Cartilage Society- International Cartilage Regeneration & Joint Preservation Society (ICS-ICRS) fellowship 2018 for the 13th ICRS World Congress held at Macau April 2018.

Awards

• Rev.Fr. Lourdu Yeddanapalli Award, 2023, Christian Medical College, Vellore.
• ICS Felicitation award at the 9th Congress of Indian Cartilage Society, Chennai for poster presentation at the International Cartilage Regeneration & Joint Preservation Society, 17th World Congress at Sitges/Barcelona, Spain.
• Third prize in the basic science faculty poster presentation at the 10th Annual Research Day held at Christian Medical College, Vellore 2021.
• Second prize in poster presentation at the 3rd International Conference on Osteoarthritis OACON held at Bangalore 2019.
• Second prize for IBOS gold medal presentation at the 2nd annual conference of the Indian Biologics Orthopaedics Society held at Sri Ramachandra Institute of Higher Education and Research, Chennai 2019.
• First prize in the basic science faculty poster presentation at the 9th Annual Research Day held at Christian Medical College, Vellore 2018.
• Junior Training Fellowship, Erasmus MC, Rotterdam Netherlands 2018.
• Indian Cartilage Society- International Cartilage Regeneration & Joint Preservation Society (ICS-ICRS) Fellowship, Macau 2018.
• First place in oral presentation at the 4th congress of the Indian Cartilage Society held at Coimbatore 2017.
• Second place in surgical specialties faculty oral presentation at the 8th Annual Research Day held at Christian Medical College 2017.
• Third place in 3-Minute Thesis (University of Queensland) competition held at Christian Medical College 2014.
• First place in poster presentation at the 59th annual conference of the Association of Physiologists and Pharmacologists of India held at NIMHANS, Bangalore.
• First place in PG oral presentation at the 7th annual conference of the Association of Physiologists of Tamilnadu (APT) held at Kilpauk Medical College, Chennai.

Research

Our goal is to characterize cartilage-derived progenitors, isolate the purer population of cells with enhanced chondrogenic potential, and apply this knowledge toward the evolution of improved therapeutics to regenerate genuine hyaline cartilage. In cartilage tissue engineering and regenerative medicine, the requirement to enhance biological and functional outcomes in improving ongoing treatment and developing new therapeutic strategies remains. Our research focuses on creating and validating osteoarthritic models in animals, characterizing cartilage-derived progenitors, and evaluating its potential implication for cartilage regeneration using in-vitro and in-vivo conditions. We hypothesize that a better understanding of these progenitors than other cell types will enable us to create a detailed biological profile and develop better approaches to treating cartilage pathologies.
In a proof of principle experiment, we observed that chondroprogenitors possess a higher chondrogenic potential and lower propensity for hypertrophy, indispensable in cartilage repair. Thus our primary focus is cartilage regeneration and joint preservation, using progenitors and assessing their efficiency in treating early-grade osteoarthritis and osteochondral defects, in addition to evaluating xeno-free alternatives, secretome characteristics, transcriptome mapping, and immunomodulation. The end goal is to establish translational research using cell isolates from the cartilage for the cartilage.

Selected Publications

• Elizabeth Vinod, Ganesh Parasuraman, Soosai Manickam Amirtham, Sandya Rani, Abel Livingston, Solomon Sathishkumar. Enhanced Visualization of Articular Cartilage ChondroprogenitorDerived Extracellular Vesicles Using Cytospin Centrifugation for Confocal Imaging” European Journal of Anatomy. Accepted on 7th February 2024.
• Esther Sathya Bama Benjamin, Elizabeth Vinod, Stallon Illangeswaran, Bharathi M Rajamani, Abhirup Bagchi, Rakhi Thalayattu Vidhyadharan, Ganesh Parasuraman, Soosai Manickam Amirtham, Shaji RV, Poonkuzhali Balasubramanian. Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSC) line retains the immunodulatory and chemoprotective properties of CML patient-derived MSCs. Cellular Signaling. January 2024. https://www.sciencedirect.com/science/article/pii/S0898656824000354?via%3Dihub
• Deena Susie Melenshia, Soosai Manickam Amirtham, Grace Rebekah, Elizabeth Vinod, Upasana Kachroo. Effect of Reconstituted, Lyophilized Cold Aqueous Extract of Aloe Vera on Human Whole Blood Clotting Time - A Pilot Study. Journal of Ayurveda and Integrative Medicine. Accepted on 13th January 2024.
• Jesi Charles, Latha Nedumaran, Swetha Raman, Elizabeth Vinod, Rajalakshmi Rajasegaran, Kamalakannan Vadivel, Anand Bhaskar, Sathya Subramani. Rhythm generating mechanisms in rat sinoatrial node. Current Medical Issues. Accepted on 10th November 2023
• Deepak Vinod Francis, Aishwarya Jayakumaran Rajeswari, John Bino Stephen, Ganesh Parasuraman, Jeya Lisha J Abel Livingston, Sandya Rani, Alfred Job Daniel, Solomon Sathishkumar, Elizabeth Vinod. An ultrastructural report of human articular cartilage resident cells in correlation with their phenotypic characteristics. Journal of Histotechnology. November 2023.
  https://www.tandfonline.com/doi/full/10.1080/01478885.2023.2278118
• Soosai Manickam Amirtham, Ganesh Parasuraman, Jeya Lisha J, Deepak Vinod Francis, Abel Livingston, Grace Rebekha, Solomon Sathishkumar and Elizabeth Vinod. Decellularized Fetal Collagen Exhibits Chondroinductive Potential for Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Glycosaminoglycan Production. European Journal of Anatomy. July 2023. https://doi.org/10.52083/KJJC3228
• Ganesh Parasuraman, Elizabeth Vinod, Abel Livingston, Solomon Sathishkumar and Deepak Vinod Francis. Comparative assessment of the morphology and antigenicity of human osteochondral units using formalin and coagulant fixative. European Journal of Anatomy. May 2023. https://doi.org/10.52083/CVZF3774
• Elizabeth Vinod, Jeya Lisha J, Ganesh Parasuraman, Abel Livingston, Alfred Job Daniel, Solomon Sathishkumar. Evaluation of Ghrelin as a distinguishing marker for human articular cartilagederived chondrocytes and chondroprogenitors. Journal of Clinical Orthopaedics and Trauma. June 2023. https://doi.org/10.1016/j.jcot.2023.102175
• Elizabeth Vinod, Ganesh Parasuraman, Jeya Lisha J, Soosai Manickam Amirtham, Abel Livingston, Jithu James Varghese, Sandya Rani, Deepak Vinod Francis, Grace Rebekah, Alfred JobDaniel, Boopalan Ramasamy, Solomon Sathishkumar. Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells. PLOS ONE. April 2023. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285106
• Elizabeth Vinod, Ganesh Parasuraman, Abel Livingston, Soosai Manickam Amirtham, Grace Rebekah, Jeya Lisha J, Alfred Job Daniel, Solomon Sathishkumar. Comparison of methods for the isolation and culture of Migratory Chondroprogenitors from Human articular cartilage. Connective Tissue Research. April 2023. https://www.tandfonline.com/doi/full/10.1080/03008207.2023.2202266
• Elizabeth Vinod, Kawin Padmaja, Boopalan Ramasamy, Solomon Sathishkumar. Systematic review of articular cartilage derived chondroprogenitors for cartilage repair in animal models. Journal of Orthopaedics. November 2022. https://doi.org/10.1016/j.jor.2022.10.012
• Kawin Padmaja, Soosai Manickam Amirtham, Grace Rebekah, Solomon Sathishkumar, Elizabeth Vinod. Supplementation of articular cartilage-derived chondroprogenitors with bone morphogenic protein-9 enhances chondrogenesis without affecting hypertrophy. Biotechnology Letters. August 2022
  https://link.springer.com/article/10.1007/s10529-022-03280-9
• Noel Naveen Johnson, Soosai Manickam Amirtham, B. Sandya Rani, Solomon Sathishkumar, Grace Rebekah, and Elizabeth Vinod. Assessment of the inherent chondrogenic potential of human articular cartilage-derived chondroprogenitors in pellet culture using a novel whole pellet processing approach. Journal of Orthopaedics, March 2022. https://doi.org/10.1016/j.jor.2022.03.007
• Elizabeth Vinod, Noel Naveen Johnson, Sanjay Kumar, Soosai Manickam Amirtham, Jithu Varghese James, Abel Livingston, Grace Rebekah, Alfred Job Daniel, Boopalan Ramasamy and Solomon Sathishkumar. Migratory chondroprogenitors retain superior intrinsic chondrogenic potential for regenerative cartilage repair as compared to human fibronectin derived chondroprogenitors. Scientific reports. November 2021. https://doi.org/10.1038/s41598-021-03082-5
• Elizabeth Vinod, Kawin Padmaja, Abel Livingston, Jithu Varghese James, Soosai Manickam Amirtham, Solomon Sathishkumar, Boopalan Ramasamy, Grace Rebekah, Alfred Job Daniel, Upasana Kachroo. Prospective isolation and characterization of chondroprogenitors from human chondrocytes based on CD166/CD34/CD146 surface markers. Cartilage. September 2021. https://doi.org/10.1177%2F19476035211042412
• Roshni Parameswaran, Upasana Kachroo, Soosai Manickam Amirtham, Grace Rebekah and Elizabeth Vinod. An invitro analysis of the effect of hyperosmolarity on the chondrogenic potential of human articular cartilage derived chondroprogenitors. Tissue and Cell. Volume 72, 2021. https://doi.org/10.1016/j.tice.2021.101590
• Soosai Manickam Amirtham, Upasana Kachroo, Deepak Vinod Francis, Kawin Padmaja and Elizabeth Vinod. An improved method for processing chondroprogenitor pellets following chondrogenic differentiation for histology and immunohistochemical staining using agarose. Journal of Arthrosopy and Surgery. May 2021. https://doi.org/10.1016/j.jajs.2021.05.005
• Elizabeth Vinod, Roshni Parameswaran, Soosai Manickam Amirtham, Grace Rebekah, Upasana Kachroo. Comparative analysis of human bone marrow mesenchymal stem cells, articular cartilage derived chondroprogenitors and chondrocytes to determine cell superiority for cartilage regeneration. Acta Histochemica. April 2021. https://doi.org/10.1016/j.acthis.2021.151713
• Elizabeth Vinod, Soosai Manickam Amirtham, Upasana Kachroo, Anjali Goyal, Ozlem Ozbey, Jithu Varghese James, Solomon Sathishkumar, Boopalan Ramasamy. Articular chondroprogenitors in platelet rich plasma for treatment of osteoarthritis and osteochondral defects in a rabbit knee model. The Knee. March 2021. https://doi.org/10.1016/j.knee.2021.03.010
• Elizabeth Vinod, Kawin Padmaja and Upasana Kachroo. Effect of human articular chondroprogenitor derived conditioned media on chondrogenic potential of bone marrow derived mesenchymal stromal cells. Journal of Orthopaedics, Trauma and Rehabilitation. March 2021. https://doi.org/10.1177/22104917211006885
• Elizabeth Vinod, Soosai Manickam Amirtham and Upasana Kachroo. An assessment of bone marrow mesenchymal stem cell and human articular cartilage derived chondroprogenitors cocultures vs. monocultures. The Knee. March 2021. https://doi.org/10.1016/j.knee.2021.02.022
• Elizabeth Vinod, Upasana Kachroo, Grace Rebekah, Bijesh Kumar Yadav and Boopalan Ramasamy. Characterization of human articular chondrocytes and chondroprogenitors derived from non-diseased and osteoarthritic knee joints to assess superiority for cell-based therapy. Acta Histochemica. June 2020. https://doi.org/10.1016/j.acthis.2020.151588
• Elizabeth Vinod, Upasana Kachroo, Grace Rebekah, Sajo Thomas and Boopalan Ramasamy. In vitro chondrogenic differentiation of human articular cartilage derived chondroprogenitors using pulsed electromagnetic field. Journal of Clinical Orthopaedics and Trauma. October 2020. https://doi.org/10.1016/j.jcot.2020.09.034
• Elizabeth Vinod, Roshni Parameswaran, Boopalan Ramasamy and Upasana Kachroo. Pondering the potential of hyaline cartilage derived chondroprogenitors for tissue regeneration: A systematic review. Cartilage. July 2020. https://doi.org/10.1177/1947603520951631
• Elizabeth Vinod, Roshni Parameswaran, Soosai Manickam Amirtham, Abel Livingston, Boopalan Ramasamy and Upasana Kachroo. Comparison of the efficiency of laminin versus fibronectin as a differential adhesion assay for isolation of human articular cartilage derived chondroprogenitors. Connective Tissue Research. April 2020
• Upasana Kachroo and Elizabeth Vinod. Comparative analysis of gene expression between articular cartilage derived cells to assess suitability of fibronectin adhesion assay to enrich chondroprogenitors​. The Knee. April 2020
• Upasana Kachroo, Boopalan Ramasamy and Elizabeth Vinod. Evaluation of CD49e as a distinguishing marker for human articular cartilage derived chondroprogenitors. The Knee. April 2020. [Link]
• Elizabeth Vinod, Boopalan Ramasamy and Upasana Kachroo.​ Comparison of immunogenic markers of human chondrocytes and chondroprogenitors derived from non-diseased and osteoarthritic articular cartilage. Journal of Orthopaedics, Trauma and Rehabilitation. April 2020. [Link] [PDF]
• Upasana Kachroo, Shikha Mary Zachariah, Augustine Thambaiah, Aleya Tabasum, Abel Livingston, Grace Rebekah, Alok Srivastava and Elizabeth Vinod. Comparison of human platelet lysate versus fetal bovine serum for expansion of human articular cartilage derived chondroprogenitors. Cartilage. March 2020
• Elizabeth Vinod, Tephilla Epsibha Jefferson, Soosai Manickam Amirtham, Neetu Prince, Tulasi Geevar, Grace Rebekah, Boopalan Ramasamy and Upasana Kachroo. Correlation between synovial fluid calcium containing crystal estimation and varying grades of Osteoarthritis using a rabbit model: Potential diagnostic tool. ​Journal of Clinical Orthopaedics and Trauma​. March 2020. [Link]
• Elizabeth Vinod, Upasana Kachroo, Soosai Manickam Amirtham, Boopalan Ramasamy and Solomon Sathishkumar. Comparitive analysis of fresh chrondrocytes, cultured chondrocytes and chondroprogenitors derived from human articular cartilage. Acta Histochemia. November 2019. [Link]
• Amritham SM, Ozbey O, Kachroo U, Ramasamy B and Vinod E. Optimization of immunohistochemical detection of collagen type II in osteochondral sections by comparing decalcification and antigen retrieval agent combinations. Clin Anat 2019. [Pubmed]
• Elizabeth Vinod, Jithu James Varghese, Upasana Kachroo, Solomon Sathishkumar, Abel Livingston and Boopalan Ramasamy. Comparison of incremental concentrations of micron-sized superparamagnetic iron oxide for labelling articular cartilage derived chondroprogenitors. Acta Histochemia. 2019. [Link]
• Elizabeth Vinod, Deepak Vinod Francis, Tripti Jacob, Soosai Manickam Amirtham, Solomon Sathishkumar, Praghalathan Kanthakumar, and Vinay Timothy Oommen. Autologous Platelet Rich Fibrin as a Scaffold for Chondrocyte Culture and Transplantation: An in Vitro Bovine Study. Journal of Clinical Orthopaedics and Trauma. 2019.
• Elizabeth Vinod, Upasana Kachroo, Ozlem Ozbey, Solomon Sathishkumar, and P. R. J. V. C. Boopalan. Comparison of Human Articular Chondrocyte and Chondroprogenitor Cocultures and Monocultures: To Assess Chondrogenic Potential and Markers of Hypertrophy. Tissue Cell. 2019; 57: 42–48. [Pubmed]
• Vinod E, Vinod Francis D, Manickam Amirtham S, Sathishkumar S, Boopalan PRJVC. Allogeneic platelet rich plasma serves as a scaffold for articular cartilage derived chondroprogenitors. Tissue Cell. 2019 Feb;56:107–13. [Pubmed] [PDF]
• Elizabeth Vinod, Ozlem Ozbey, Arumugam Sabareeswaran, Upasana Kachroo, Solomon Sathishkumar, and P. R. J. V. C. Boopalan. Comparison of Monosodium Iodoacetate Model of Osteoarthritis between in-Vivo and Ex-Vivo Osteochondral Unit in Rabbits. Journal of Clinical Orthopaedics and Trauma. 2018. [Link]
• Elizabeth Vinod, Jithu Varghese James, Arumugam Sabareeswaran, Soosai Manickam Amirtham, George Thomas, Solomon Sathishkumar, Ozlem Ozbey, and P. R. J. V. C. Boopalan. Intraarticular Injection of Allogenic Chondroprogenitors for Treatment of Osteoarthritis in Rabbit Knee Model. Journal of Clinical Orthopaedics & Trauma. 2018 [Link] [PDF]
• Upasana Kachroo, Abel Livingston, Elizabeth Vinod, Solomon Sathishkumar, and P. R. J. V. C. Boopalan. Comparison of Electrophysiological Properties and Gene Expression between Human Chondrocytes and Chondroprogenitors Derived from Normal and Osteoarthritic Cartilage. Cartilage. 2018 [Link]
• Vinod E, Boopalan P, Arumugam S, Sathishkumar S. Creation of monosodium iodoacetate-induced model of osteoarthritis in rabbit knee joint. Indian J Med Res 2018;147:312-4. [Link] [PDF]
• Premkumar K, Vinod E, Sathishkumar S, Pulimood AB, Umaefulam V, Prasanna Samuel P and John TA. Self-directed learning readiness of Indian medical students: a mixed method study. BMC Med Educ. 2018 Jun 8;18(1):134. [Pubmed] [PDF]
• Upasana Kachroo, Elizabeth Vinod, Sivakumar Balasubramaniam, Jesi W and Neethu Prince. Red cell indexes made easy using an interactive animation: do students and their scores concur? Adv Physiol Edu. 2018 Mar;42(1):50-55. [Pubmed] [PDF]
• Vinod E, Boopalan PRJVC and Sathishkumar S. Reserve or resident progenitors in cartilage? Comparative analysis of chondrocytes versus chondroprogenitors and their role in cartilage repair. Cartilage 2017. [Pubmed]
• Elizabeth Vinod and Elizabeth Tharion. Correlation among cardiac autonomic function tests in normal subjects. University Journal of Pre and Para Clinical Sciences. 2016: 2(4).

Internal Collaborators:

• Department of Physiology, Christian Medical College, Vellore
  (Collaborators: Dr. Solomon Sathishkumar, Dr. Soosai Manickam Amirtham)
• Department of Orthopaedics, Christian Medical College, Vellore
  (Collaborators: Dr. Alfred Job Daniel, Dr. Abel Livingston, Dr. Viju Daniel Varghese)
• Centre for Stem Cell Research, Christian Medical College, Vellore
  (Collaborator: Dr. Gurubind Singh)
• Department of Anatomy, Christian Medical College, Vellore
  (Collaborators: Dr. Deepak Vinod Francis, Dr. John Binu, Dr. Aishwarya Jayakumar)
• Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore
  (Collaborators: Dr. Dolly Daniel)

External Collaborators:

• Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
  (Collaborator: Dr. Boopalan Ramasamy)
• Department of Orthopaedics and department of Otorhinolaryngology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.(Collaborator: Prof. G.J.V.M Van Osch)
• Department of Pathology, Smt NHL Municipal Medical College, Ahmedabad, India
  (Collaborator: Dr. Anjali Goyal)
• Department of Histology and Embryology Campus, School of Medicine, Akdeniz University, Antalya, Turkey
  (Collaborator: Dr. Ozlem Ozbey)
• Department of Diabetes, School of Life Course Sciences, King's College London, London, UK
  (Collaborator: Dr. Jithu Varghese James)
• Department of Anatomy, Histology, Embryology, Faculty of Medicine, University of Debrecen, Hungary
  (Collaborator: Dr. Csaba Matta)

Will be updated soon

Will be updated soon